儿童支气管哮喘血清可溶性细胞间粘附分子1的变化及其临床意义

The clinical significance of serum concentration of soluble intercellular adhesion molecule-1 in children with asthma

目的 探讨可溶性细胞间粘附分子 1(sICAM 1)在儿童支气管哮喘发病机制中的作用。方法 测定 2 7例支气管哮喘儿童急性发作期血清sICAM 1的水平 ,其中有 18例测定了恢复期血清sICAM 1的水平 ,同时以 16例正常儿童血清sICAM 1作对照。结果 支气管哮喘儿童血清sICAM 1在急性期和缓解期均较正常对照组升高 ,差异有显著性 (P <0 0 5 )。重度哮喘发作儿童较轻、中度发作升高更显著 (P <0 0 1)。结论 sICAM 1参与了儿童支气管哮喘的发病 ,可作为判断病情严重程度的重要指标之一。

Objective To evaluate the effect of soluble intercellular adhesion molecule 1(sICAM 1) in pathogenesis of children with asthma.Methods Serum sICAM 1 was measured in 27 children with asthmatic acute attack,18 children in asthmatic remission and 16 healthy controls.Results The level was greatly increased in asthmatic acute attacks and remission period.The level was also greatly increased in severe asthmatic acute attacks than in mild or moderate attacks.Conclusion We suggest that sICAM 1 may play a role in pathogenesis of children with asthma.It serves as an important index in judging the severity of asthma.