经面罩持续气道正压治疗急性肺损伤致呼吸衰竭的临床研究

Treatment of acute respiratory failure caused by acute lung injury with continuous positive airway pressure with face mask

目的 评价经面罩持续气道正压通气 (CPAP)治疗急性肺损伤致呼吸衰竭的疗效。方法 6 7例患者被随机分为CPAP治疗组和对照组 ,比较 2组治疗 1、2 4h后的动脉血气值、呼吸频率和脉率及 1h后的主观效果。结果 1h时CPAP治疗组较对照组明显改善动脉血氧合 ,降低呼吸频率和脉率 ,改善临床症状。 2 4h后两组结果无明显差异。结论 CPAP应用于急性肺损伤所致呼吸衰竭时 ,虽可改善早期生理状况 。

Objective To evaluate the efficacy of continuous positive airway pressure (CPAP) administered by face mask in patients with respiratory failure caused by acute lung injury with indication of mechanical ventilation.Methods Sixty-seven adult patients in acute respiratory failure caused by acute lung injury were divided into control groups and CPAP groups randomly.After the treatment of 1,24 h of two groups,pH,PaO 2,PaCO 2,SaO 2,respiratory rate (f) and heart rate were measured.Compare the data and subjective effect after 1 h of two groups.Results The use of CPAP by face mask significantly improved the arterial blood oxygenation and subjective effect and decreased the respiratory rate and heart rate after the treatment of 1h (P<0 05),but there had no evidence to show difference in two groups after 24 hours.Conclusions These data allow the conclusion that CPAP administered by face mask improves the physio-status of acute lung injury caused respiratory failure,but couldn't ameliorate its prognosis