补中益气汤治疗肠应激综合症303例

Treatment of Mesenteric Stress Syndrome with Buzhong Yiqi Decoction(补中益气汤),a Report of 303 Cases

选符合诊断标准的肠应激综合症患者 4 5 3例 ,采用双盲随机法分为治疗组 30 3例 ,对照组 15 0例。治疗组予补中益气汤治疗 ,对照组应用谷维素、色甘酸钠。结果 :治疗组痊愈 2 2 3例 ,显效 6 1例 ,有效 10例 ,无效 9例 ,总有效率为 97.0 3% (95 %CI=95 .12 %～ 98.94 % ) ;对照组痊愈 10例 ,显效 32例 ,有效 6 1例 ,无效 4 7例 ,总有效率为 6 8.6 7% (95 % CI=6 1.2 5 %～76 .0 9% ) ;治疗组综合疗效明显优于对照组 (采用 Ridit分析 ,u=13.86 5 4 ,P<0 .0 0 0 1) ;且两组 95 %的可信区间不重叠 ;治疗组发生无效患者的危险性较对照组低 (OR=0 .0 6 7,95 % CI=0 .0 31～ 0 .14 2 ) ,治疗组每治疗 3.5人 ,可较对照组减少 1例无效患者 (NNT=3.5 ,95 % CI=2 .9～ 4 .6 )。整个结论 95 %的可信区间范围狭小 ,可信度强 ,基本满足循证医学一级证据条件。

Four hundred and fifty three cases of mesenteric stress syndrome were randomly divided into the treatment group(303 cases),and the control group (150 cases).The patients in the treatment group were treated with Buzhong Yiqi Decoction(补中益气汤,BYD),and the patients in the control group were treated with glutamic acid and disodium cromoglycate.Result:In the treatment group,223 cases were cured,61 cases were markedly effective,10 cases effective,9 cases were ineffective and the total effective rate was 97.03%(95%CI=95.12% 98.94%).In the control group 10 cases were cured,32 cases were markedlyeffective ,61caseswereeffective ,47caseswereineffectiveandthe total effective rate was 68.67%(95%CI=61.25% 76.09%).The effect difference between the two groups was significant(P<0 0001).