E-cadherin在乳腺癌中的表达及其临床意义

E-cadherin Expression in Breast Carcinoma and Its Clinical Significance

目的 :研究上皮钙黏附素 (epithelialialcadherin ,E cadherin)表达与乳腺癌生物学行为的关系及对预后的意义。方法 :采用免疫组织化学方法检测 5 1例乳腺浸润性导管癌组织E cadherin表达水平 ,并对其与乳腺癌临床病理特征和术后生存时间的关系进行统计学分析。结果 :本组 5 1例中E cadherin高表达者 2 1例 ,占 4 1 2 % ;低表达者 30例 ,占 5 8 8%。E cadherin表达水平与肿块大小、腋淋巴结状态、TNM分期、组织学分级、复发和转移相关 ;单因素生存分析提示E cadherin高表达组术后 5年生存率高于低表达组 ;Cox比例风险模型多因素分析显示E cadherin表达水平是乳腺癌的独立预后指标。结论 :E cadherin表达下调促进肿瘤恶性进展 ,可作为乳腺癌失分化和强侵袭性行为的指标。E

Objective To investigate the expression of E cadherin in breast carcinoma in relation to biological behavior and prognosis.Methods Expression of E cadherin protein was detected by immunohistochemical technique in 51 breast invasive ductal carcinoma specimens.The relationship of E cadherin expression to clinicopathological characteristics and postoperative survival time was statistically analysed.Results Of the 51 cases,the high and low E cadherin expressive rate was 41 2% (21/51) and 58 8% (30/51) respectively.E cadherin expression level was correlated with tumor size,axillary lymph node status,TNM stage,histological grade,local recurrence and distant metastasis.Univariate survival analysis demonstrated that patients with high E cadherin expression showed better postoperative 5 year survival.Cox multivariate analysis showed that E cadherin expression level was an independent prognostic marker.Conclusions Reduced E cadherin expres sion in breast carcinoma promotes malignant progression,and indicates dedifferentiation and intensive invasive biological behavior.E cadherin expression level is an independent prognostic factor in breast carcinoma.