三株草鱼出血病病毒免疫原性的比较

Comparison of the Immunogenicity of Three Grass Carp Hemorrhage Viruses

从湖南邵阳、湖北仙桃、武汉南湖地区分离到的三株草鱼出血病病毒(GCHV873、GCHV875、GCHV876),分别对家兔进行免疫,并测定了它们在家兔体内形成抗体的水平以及这些抗体对相应抗原的中和能力。实验结果显示:GCHV873产生抗体滴度比GCHV875高一倍,较GCHV876高8倍;其抗体的中和效价分别是1:1778(10^(-3.25))、1:386(10^-(2.59))和1:181(10^-(2.25))。上述结果表明:GCHV873的免疫原性是三个分离株中最强的一个毒株。

The immunogenic comparison of three grass carp hemorrhage viruses, GCHV873, GCHV875 and GCHV876 derived from different areas has been carried out on the basis of the levels of the elicited serum antibodies in rabbits. The anti-GCHV873 antibody titre was 2 folds higher than GCHV875 and 8 folds than GCHV876. Their neutralizing titres were 1 : 1778(10^(-3.25)), 1: 386(10^(-2.59)) and 1: 181(10^(-2.25)) respectively.These experimental results suggested that GCHV873 is a stronger immunogen among three isolates.