转移性肺癌镂空放疗技术及疗效初步总结

Radiotherapy of Polytopy Lung Metastasis with Hollowed-cut Alloy Lead

目的 :评价放射治疗在多发性转移性肺癌中的价值。方法 :对 2 3例多发性转移性肺癌运用镂空式挡块放疗。每野每次Dm 3Gy ,每天 1次 ,每周 5次 ,每野总DT5 0～ 6 5Gy。以近期疗效、远期疗效评价放疗效果 ,以肺功能评价副作用。结果 :多发性转移性肺癌运用镂空式挡块放疗后 ,CR 13% (3/2 3)、PR 6 5 % (15 /2 3)、NR +PD 2 2 % (5 /2 3)、未作放疗组CR 5 % (1/2 1)、PR 2 1% (2 4 /2 1)、NR +PD 71%(15 /2 1)、放疗组CR +PR显著优于未作放疗组 (P <0 0 1)。远期疗效 :放疗组中位生存期 18个月 ,未放疗组中位生存期 9个月。 1年生存率放疗组 6 7% (16 /2 4 ) ,未放疗组 38% (8/2 1)。 18个月生存率放疗组 16 % (6 /2 4 ) ,未放疗组 4 % (1/2 1)。放疗后 1年生存率放疗组显著优于未放疗组 (P <0 0 1)。放射治疗前后 ,肺功能未发现明显改变。结论 :镂空式铅模治疗多发性肺转移有效 ,副作用轻 ,在改善生存质量同时 。

Objective To evaluate the value of Radiotherapy for polytopy lung metastasis.Methods From 1995 to 1998,23 cases of polytopy lung metastasis were treated with hollowed cut alloy lead.The overall patients received D T 50-60 Gy per portal,2 Gy twice daily,5 days per week.Pulmonary function was completed upon 4 to 8 weeks after irradiation.Results The response was CR 13%(3/23),PR 65%(15/23),NR+PD 22%(5/23),respectivelg.The 12 month,18 month survival rates were 67%,16% in radiotherapy group and 38%,4% in no radiotherapy group.The results showed no significantly decrease in prameters on pulmonary function in radiotherapy group.Conclusions Radiotherapy of polytopy lung metastasis with hollowed cut alloy lead is able to raise the local control rate and improve survival rates partly without obvious changes on pulmonary functions.