X-刀对非肝癌组织的放射性效应

Radioactive effect of X-knife on non-cancerous liver tissues

目的 研究具有不同内在因素的肝癌在X -刀作用下对非癌组织的放射性效应。方法 选择肝癌体积、X 刀剂量基本相似条件下 ,以ALT(丙氨酸氨基转移酶 )为指标观察具有不同内在因素的肝癌于X 刀术后发生放射性肝损伤的危险性。结果 原发性肝癌于X 刀术后ALT上升值与术前比较具有显著性差异 (P <0 .0 0 1 )。原发性肝癌与转移性肝癌于X 刀术后ALT升、降之差及上升率比较差异非常显著 (P <0 .0 0 1 .P <0 .0 1 )。同时发现X 刀对原发性肝癌组中HBVM(+)和嗜酒因素均有者发生放射性肝损伤的危险性与这两种因素均无者比较差异非常显著 (P <0 .0 0 1 ,OR=2 7.5) ;与转移性肝癌比较亦具有非常显著性差异 (P <0 .0 0 1 ,OR =2 8.2 85)。结论 在X 刀治疗肝癌中对非癌肝组织具有放射性损伤者占 39.1 8% ;其程度及发生率以原发性肝癌为高 ,以同时伴有HBVM(+)及嗜酒因素者为重。

Objective To research the radioactive effect of X knife on non cancerous tissues in liver cancer patients with different inherent factors.Methods Under the conditions of the same size liver cancer and the similar dosage of X knife and by using ALT as index,the risk factors of liver damage were observed after the operation of X knife on liver cancer patients with different inherent factors.Results After the X knife operation,ALT rose in the primary liver cancer patients,(P<0.001).There was a sharp difference between primary liver cancer and metastatic liver cancer after X knife operation in the rise and fall of ALT and its rising rate,(P<0.001 and P<0.01).The radioactive liver damage in primary liver cancer patients with HBVM(+)and heavy drinking was severer than those without,(P<0.001,OR=27.5) and also severer than metastatic liver cancer patients,(P<0.001,OR=28.285).Conclusion There still exists radioactive damage to liver in the treatment of liver cancer with X knife(39.18%).The incidence is higher in primary liver cancer patients and serious in patients with HBVM(+) and heavy drinking.