摘要
本实验用40只封闭群新西兰白兔,观察了侧脑室灌注Tau、CaCl_2对家兔ET性发热及EGTA性发热的影响。结果表明:侧脑室灌注Tau能明显抑制家兔ET性发热及EGTA性发热;一旦停止灌注Tau,体温又上升,后者可被侧脑室灌注CaCl_2所阻断。结果提示:Tau很可能是通过增加丘脑下部脑组织Ca^(++)含量,使Na^+/ca^(++)比值回降而抑制发热的。
40 New Zealand white rabbits were used to observe the effect on the fever caused by ET (endotoxin) and EGTA [ethylene glycol bis-(β-aminoethylethylether)-N, N, N′, N′-tetraacetic acid] after ICV (intracerebroventricular) infusion of Tau and CaCl_2 into rabbits. The results showed that Tau ICV perfusion could inhibit the initial febrile response to ET and EGTA in rabbits (P<0.01). When the perfusion of Tau was stopped, the rectal temperature continued to rise (P>0.05), which could be blocked by ICV infusion of CaCl_2. The authors suggested that Tau might increase the level of Ca^(++) in the hypothalamus and reduce Na^+/Ca^(++) ratio, then lower the fever.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第4期353-355,共3页
Chinese Journal of Pathophysiology
基金
广东省科委自然科学基金
