急性心肌梗塞表观粘度、全血粘弹性和泵功能关系初探

Preliminary study of relationship between appparent viscosity,viscoelastic properties of whole blood and cardiac function in patients with acute myoeardiae infarction

采用Low Shear—30流变仪,对急性心肌梗塞(AMI)和心绞痛(AP)各10例,在切变率(γ)范围0.376～128.5s^(-1)下测其表观粘度(ηa),并测定全血粘弹性参数(粘性分量η′、弹性分量η″、弹性模量G′和损失模量G″)和心脏泵功能参数,同时与正常人(NS)11例对照。结果:AMI组在高、中和低切变率下的ηa和上述粘弹性参数均高于AP组和NS组(P<0.05～0.01),泵功能参数(EF、SV、CO、LVET、PEP/LVET、HI和Cl)却低于AP组和NS组(P<0.05～0.01)。本文研究提示AMI的泵功能受损与其血液流变特性异常有关;纠正血液流变特性异常的方法或措施有利于AMI的治疗。

Using Low Shear-30 rheometer, we studied apparent viscosities at high (51.2-128.5s^(-1)), moderate (11.02-37.6s^(-1)), and Low (0.376-8.11s^(-1)) shear rate, viscoelastic properties of whole blood and hemodynamic parameters in 10 patients with acute myocardiac infarction(AMI), comparing with 10 patients with angina pectoris (AP) and 11 normal subjects(NS). It was demostrated that the apparent viscosities of whole blood at different shear rates mentionned above and viscoelastic properties of whole blood (the dynamic modulus G′, the loss modulus G″, 'the viscous η′ and the elastic component η″ of complex viscosity) increased distinctly and parameters of cardiac function (EF, CO, LVET, PEP/LVET, HI, SV and CI) were abnormal obviously in AMI, in comparing with AP and NS (P<0.05 or P<0.01), reduction in cardiac function in AMI is related to changes of blood theological properties. The results suggest that restoring the rheological properties of whole blood may be beneficial in the treatment of AMI.