儿茶酚-O-甲基转移酶基因多态性与精神分裂症发病特点的关系

Association analysis of schizophrenia with catechol-O-methyltransferase gene polymorphism

目的 :在中国汉族人群中寻找儿茶酚 O 甲基转移酶 (catecholamine O methyltransferase,COMT)基因Val15 8Met多态性与精神分裂症发病特点之间的关系。方法 :使用病例 对照研究方法 ,对符合诊断标准的 476名精神分裂症患者 / 2 0 7名正常对照就COMT基因Val15 8Met多态性进行检测并进行关联分析。结果 :(1)非慢性患者的Val15 8Val基因型Val15 8等位基因分布频率显著高于对照组 ,对年龄、性别等调整后结果仍然成立 ;(2 )早发病组 (2 5岁前起病 )患者杂合子 (Val15 8Met)及等位基因Met15 8分布频率显著高于晚发病组 (P <0 .0 5 )。结论

Objective: To investigate the association of Val158Met polymorphism in the catechol-O-methyltransferase gene exon IV with schizophrenia in Chinese Han population. Methods:The case-control association study was adopted to analyze the association between the Val158Met polymorphism in the catechol-O-methyltransferase gene exon IV with 476 DSM-IV schizophrenics and 207 psychiatrically normal controls. Results: (1) The frequencies of Val158Val genotype and Val158 in the patients with less than 5-year course were significantly higher than those in the controls (Val158Val: 62.6% vs 49.8%, P<0.05; Val 158∶80.4% vs 70.8%),and the differences still existed when the age and sex were adjusted; (2) Among the patients, the frequencies of heterozygosity genotype and allele Met158 of those with onset age before 25 years old were significantly higher than those after 26 years old(P<0.05). Conclusion: The findings suggest that the COMT gene polymorphism is associated with schizophrenia or its clinical features.