摘要
目的 :探讨食道静脉破裂出血内镜治疗中的血浆降钙素基因相关肽水平变化的机理。方法 :自 1 999年 4月以来 ,在 47例肝硬化食道静脉破裂出血患者中 ,随机选择 2 7例应用硬化剂治疗 ,2 0例使用套扎治疗。应用放射免疫分析法测定 47例患者治疗前后的血浆CGRP水平的变化及临床意义。结果 :硬化剂组血浆CGRP水平治疗前CGRP(87± 2 3)ng/L ,显著高于治疗后 (55± 2 8)ng/L ,P <0 .0 5 ;套扎器组治疗前CGRP(1 0 3± 2 7)显著高于治疗后CGRP(79± 2 0 ) ,P <0 .0 1 ;硬化与套扎二组比较 ,患者的血浆CGRP水平无显著性相关。结论 :在食道静脉破裂出血的内镜治疗中 ,应用硬化剂与套扎是一种有效的方法 ,其机制与影响CGRP基因表达。
Objective:To sum up the experience of use of endoscope treatment in acute oesphageal variceal bleeding and Changes of calcitonin gene -related peptide level (CGRP).Methods:Since April 1999, 47 patients have undergone acute oesphageal variceal bleeding,of them, 27 patients were randomly selected to receive sclerosing agent and 20 patients were randomly selected to receive snare treatment.The level of calcitonin were obversed.Results:In reptilase add sandostatin group,the operation field was clean,postoperative oozing of blood was markedly decreased and no adverse reactions were found.Conclusion: The application of sclerosis and prick was a therapy operative method in esophagovein disrupt hemorrhagic, and it is related with CGRP gene expression and hemodynamics disorder.
出处
《中国内镜杂志》
CSCD
2002年第7期47-49,共3页
China Journal of Endoscopy