小儿肾小球疾病肾活检110例临床分析

Analysis of clinical pathological manifestations in 110 children with glomerular nephropathy

目的 探讨小儿肾小球疾病的病理特点及其与临床表现的关系。方法 对 110例符合肾小球疾病诊断标准的小儿行肾活检术 ,肾组织送光镜、电镜及免疫荧光检查。结果 110例肾组织病理改变为 :IgA肾病 32例 (2 9.1% ) ;系膜增生 2 1例 (19.1% ) ;薄基底膜肾病 18例 (16 .4 % ) ;膜增生性肾炎、Alport综合征及微小病变各 6例 (5 .5 % ) ;局灶增生和轻微病变各 4例 (3.6 % ) ;新月体肾炎及增生硬化性肾炎各 3例 (2 .7% ) ;局灶节段性硬化、膜性肾病和IgM肾病各 2例 (1.8% ) ;毛细血管内皮增生 1例 (0 .9% )。 结论 相同的临床诊断 ,其病理表现可不同 ;相同的病理诊断 。

Objective To study the characteristics of glomerular pathological patterns and their relationship with clinical manifestations in children.Methods 110 children with glomerular nephropathy were given renal biopsy,all specimen were examined by light microscpy,electron microscopy and immunofluorescence.Results The main pathological patterns were:IgA nephropathy 32 cases(29.1%);mesangial proliferative glomerulonephritis 21 cases(19.1%);thin basement membrane nephropathy 18 cases(16.%);membranoproliferative glomerulonephritis?Alport syndrome and minimal change were the same 6 cases(5.5%);focal proliferative and minor change were the same 4 cases(3.6%);proliferative sclerosing glomerulonephritis and crescentic glomerulonephritis 3 cases (2.7%) each;IgM nephropathy,focal segmental glomerulos clerosis and membranous nephropathy 2 cases (1.8%) each;etc. Conclusions The same clinical diagnosis may have different pathological changes and one pathological pattern may present different clinical features.