48例慢性肺间质疾病临床特征及肺功能分析

Analysis of clinical features and pulmonary function of 48 cases with chronic interstitial lung disease

目的 通过回顾性总结 ,提高对慢性肺间质病的认识。方法 回顾性分析 4 8例慢性肺间质纤维化患者的临床特点和肺功能情况。结果 4 8例患者分为二组。特发性肺间质纤维化 (IPF)组 2 6例 (5 4 % ) ,继发性肺间质纤维化组 2 2例 (46 % )。IPF组年龄偏大 ;多数有爆裂音 ,占 39.6 % (19/ 4 8) ,杵状指者占 10 .4 % (5 / 4 8) ;CT/HRCT表现比较典型。两组肺功能改变主要为限制性的通气障碍和弥散功能降低。IPF组肺活量 (VC)和肺总量(TLC)较继发性组下降明显 ,P <0 .0 5。一秒率 (FEV1% )在正常范围 ,一氧化碳弥散量 (DLCO)下降显著且早 ,是较敏感的基础肺功能指标。

Objective To raise high the recoganition of chronic interstitial lung disease and strengthen the clinical work.Methods Studying retrospectively the clinical data and pulmonary function in 48 cases diagnosed interstitial lung disease in the department of respiratory diseases from 1990 to 2000.Results 26 male 22 female of 48 patients,age ranging from 30 to 80 years old,mean age 66±12.26 cases of IPE(54% ILD),22 cases of secondary interstitial lung diseases (46% ILD),age of IPF group was older than secondary ILD group ( P <0.05).Most patients had crackle or velcro and clubbing finger especially obvious CT/HRCT photograph.Pulmonary function revealed no significant difference in percent predicted FEV1 between 2 groups but significantly lower VC and TLC in IPF patients ( P <0.05);DLCO decreased not only early and significantly,but also was sensitive to ILD.Conclusions IPF differs from secondary interstitial lung diseases in clinical features and pulmonary function.