双中心协同催化作用在不对称合成中的应用

Two-Center Catalysis in Asymmetric Synthesis

介绍了双中心协同催化作用的概念以及A型和B型两类催化剂 .综述了A型催化剂在不对称硝基 -类羟醛反应、迈克尔加成反应、亚胺和醛的氢膦酰化反应、曼尼希反应、不对称醛酮羟醛反应以及环氧开环反应中的应用 ;

The concept of two-center catalysis and two kinds of catalysts, type A and type B, were reviewed. The type A catalyst can be used in asymmetric nitro-aldollike reaction, Michael addition reaction, imine and aldehyde hydrophosphonylation, Mannich reaction, asymmetric aldol reaction of aldehyde with unmodified ketone, and epoxide ring-openning reaction. The use of type B catalyst in asymmetric synthesis is also discussed.