四例女性地方性克汀病病理形态学观察

AN OBSERVATION OF PATHOLOGICAL MORPHOLOGY IN 4 FEMALE CASES WITH ENDEMIC CRETINISM

本文报告4例女性地克病尸检材料的光镜和电镜定位观察。所见甲状腺部分滤泡上皮细胞变性坏死,新旧病灶同时存在;甲状腺病变与垂体代偿性增大、生长发育障碍及T_3、T_4、TSH的变化密切相关;中枢神经系统的病变主要表现为感觉、运动神经细胞两种不同的变性坏死,其病变分布广泛,主要分布在灰质;作者还分析了橄榄核、丘脑、脊髓、小脑、中脑病变与智力、语言、运动,听力、表浅感觉障碍的关系;并对性腺发育亦做了初步探讨。

This paper reports localization observation of the autopsy in 4 female cases with endemic cretinism under light and electron microscope. The degeneration and necrosis of follicular epithelial cells of thyroid were partly showed and the new and old focuses existed at the same time. There was a direet relationship and compensatory enlargement of pituitarium, the retardation in growth and the chang in T_3、T_4、TSH. The lesions of the central nervous system were mainly two different kinds of degeneration and necrosis occurred in sensory and motor cells and were mainly distributed in cineren The relations between lesions and intelligence, language, movement, hearing and superficial sensibility were analysed. The problems about the genitality of patients with endemic cretinism are also discussed here。