FHIT和p53在胃癌中的表达及其意义

FHIT AND P53 GENE EXPRESSION IN HUMAN GASTRIC CARCINOMA

目的 :探讨脆性组氨酸三联体 (FHIT)基因和p5 3基因在胃癌中的表达及其与临床病理因素的关系。方法 :采用免疫组化SP法检测 78例胃癌组织中FHIT和p5 3的表达。结果 :FHIT和 p5 3在胃癌中表达率分别为 4 3.6 %和 5 2 .6 %。FHIT蛋白的丢失在胃癌中占 5 6 .4 % ,两者与胃癌的组织类型、浸润深度、临床分期和淋巴结转移状况无关 (P >0 .0 5 )。结论 :①胃癌组织中FHIT蛋白的丢失是频发事件 ,FHIT可能是胃癌发生中重要的候选抑癌基因 ;②测定FHIT和p5 3的表达 。

Purpose: To investigate the expression of fragile histidine triad(FHIT) and p53 in gastric carcinoma(GC) and their relationship to clinicopathological factors. Methods: Seventy eight cases of GC were studied using immunohistochemical technigue. Results: The positive rates of FHIT and p53 gene expression were 43.6 % and 52.6 % respectively. No correlation was found between the FHIT and p53 expression and their clinicopathological factors such as histological type, lymph node metastasis and staging. Conclusion: ① Loss of FHIT expression is a frequent event in GC and FHIT gene may be one of the important candidate tumor suppressor gene in carcinogenesis of GC; ② Detection of FHIT and p53 expression in biopsy specimens might be useful in screening of high risk population.