替硝唑对诱发性大鼠根尖周炎的作用效应

Effect of Tinidazole on the induced rat periapical periodontitis

目的 :探讨替硝唑对诱发性大鼠根尖周炎的作用效应。方法 :暴露磨牙牙髓 ,T组于术后每天腹腔注射 4mL/L替硝唑液至处死 ,C组注射生理盐水。两组分别于术后 0、3、7、14d处死作牙髓、根尖周组织学观察。结果 :T组在 3、7d时牙髓、根尖周炎症细胞浸润程度均较C组轻。结论 :替硝唑可有效地抑制大鼠根尖周炎活动期的炎症细胞浸润。

AIM:To investigate the effect of Tinidazole on induced rat periapical periodontitis.METHODS:Pulps of rat molars were exposed. 4 mL/L of Tinidazole solution was injected to the rats in T group, and the physiological saline solution in C group, all by way of by intraperitoneal administration.At different periods(O,3,7,14 d)after operation,the rats were sacrificed and microscopical analysis of the pulp and periapical tissues were performed according to histological criteria.RESULTS:At the 3 d and 7 d period,the degree of inflammatory cell infiltration in T group were less than that in C group.CONCLUSION:Tinidazole could control the induced rat periapical periodontitis effectively by inhibiting the inflammatory cell infiltration in the active phase.