克山病与环境硒等生命元素的关系

New progress in the causal association of Keshan Disease with environmental Selenium in China

通过对病带15省、区217个点进行点面调查、内外环境动态监测、地理生态系物质匹配采样、特异点21种生命元素对比分析等,从全国、省、特异点三个层次系统地阐释了环境低硒是克山病区的共同特征,从大范围揭示了80年代以来克山病发病下降和病区人群硒摄入上升的紧密关系,为克山病与元素硒的联系提供了新论据;提出了以低硒为主及其有关元素或某些因子失衡与克山病的关系,并据此提出了控制克山病的经济—生态法新对策;

By means of those studies such as investigation at key point—extensive area, dynamic monitoring on internal and external environments in fixed stations,matching sampling for geographical ecological substances comparrtive analysison 21 life elements,e.g Se etc in specific points and diet survey in Keshan disesebelt(including 217 villages in provinces or autonomoues regions)it has been interpretedsystemically through three different levels—national scale provincial(or autonomo-ues regien)and specific points that low Selenium in the environment is the commoncharacteristics for Keshen disease area.It is revealed from extensive scope that thedecreasing on incidence of Keshan disease is closely related with the increasingof Se intake for local residents in disease area since 1980's,which provided newevidence for aetiological relation with Se and Keshan disease.The compound causalmodel of Keshan disease is proposed that is low Se as major feature with imbala-nce of some essential elements and amino acids and high level of some element as antigonist factor.The formation of low Se environment is expounded deeply and based on this theeconomic—ecological approach as new countermeasure is presented for diseaseeontrol.All of these enriched the scientific theory of environmental life elements and human health.