补肾壮骨胶囊对去势雌性大鼠骨质疏松症的影响

EfiFects of Invigorating the Kidney and Strengthening the Bones Capsule on Osteoporosis in Ovariectomized Rats

目的:了解补肾壮骨胶囊对卵巢切除大鼠骨质疏松症的治疗作用。方法:采用临床检验方法测定补肾壮骨胶囊对卵巢切除大鼠血清钙、磷、血清碱性磷酸酶的影响,用骨形态计量学方法检测补肾壮骨胶囊对卵巢切除大鼠右后肢股骨治疗反应。结果:与假手术组相比,模型对照组的血钙、血磷显著下降,碱性磷酸酶升高。相对骨体积明显缩小(P<0.01)。与模型对照组相比,补肾壮骨胶囊高、低剂量组血钙、血磷显著升高,碱性磷酸酶下降,相对骨体积明显增加(P<0.05)。结论:补肾壮骨胶囊对卵巢切除大鼠骨质疏松症有明显的防治作用。

Objective:To study the therapeutic effects of inrigorating the kidney and strengthening the bones capsule(IKSBC) on osteo-porotic ovariectomized(OVX)rat model. Methods:The concentrations of calcium, phosphorus and ALP in serum of ovariectomized rats were de- termined by clinical biochemical assay, and the right hind leg thighbones of ovariectomized rats were reserved for the preparation of bone specimens and were studied by bone histomorphometry. Results: After treatment with IKSBC, the concentrations of calcium and phosphorus in ovariectomized rat serum were increased, the activity of ALP was decreased and the percentage of relative trabecular volume was increased significantly as compared with that before treatment(P< 0.05) . Conclusion: IKSBC possesses some therapeutic effects on osteoporotic rat model.