扩张型心肌病患儿血清一氧化氮含量变化及其与左室功能关系

Primary study on the relationship between the dynamic changes of the serum nitric oxide and left ventricular function in children with the dilated cardiomyopathy(DCM)

为探索扩张型心肌病 (DCM )患儿血清一氧化氮 (NO)含量的变化及其与左室功能的关系 ,检测26例DCM患儿血清NO水平及左室射血分数 (LVEF) ,并以34例健康儿童血清NO含量作为对照。结果显示 ,DCM患儿血清NO含量较正常儿童明显增高 (P<0.01) ,并与LVEF呈显著负相关 (r= -0.80,P<0.01)。

In order to study the dynamic changes of the serum nitric oxide and its relationship with the left ventricular function in children with dilated cardiomyopathy,the serum level of the nitric oxide and the left ventricular ejection fraction were checked in 26 children with dilated cardiomyopathy and 34 children in good health as control group.The results showed that the levels of serum nitric oxide in children with DCM were significantly higher than that in control group and had negative relationship with the left ventricular ejection fraction.The reduction of cardiac function in children with DCM may be related to the excessive production of the nitric oxide.