妊娠合并肝内胆汁郁积症的围生儿结局57例分析

57 cases report of the effect of intrahepatic cholestasis of pregnancy on perinatal infants

目的 探讨妊娠合并肝内胆汁郁积症 (ICP)患者致围生儿不良结局的相关指标。方法 总结本院 5 7例ICP患者的相关临床资料 ,将其与围生儿结局进行分组对照分析。结果 血清胆汁酸升高与围生儿不良结局关系不明显 (P >0 0 5 ) ;血清转氨酶水平在产生围生儿不良结局组与未产生围生儿不良结局组之间有显著性差异 (P >0 0 1) ;皮肤瘙痒持续时间大于 3周组围生儿不良结局发生率与持续时间小于 3周组有显著性差异 (P <0 0 5 ) ;有、无NST基线变异消失组的围生儿不良结局发生率有极显著性差异 (P <0 0 1)。结论 血清转氨酶水平、皮肤瘙痒持续时间及NST基线变异是否消失是预示围生儿不良结局的相关指标。

Objective To investigate related indexes of the effect of intrahepatic cholestasis of pregnancy (ICP) on perinatal infants. Methods Clinical materials of 57 cases with ICP in our hospital were collected and contrastively analyzed with the state of perinatal infants.Results Increase of serum bile acid was not significantly relative to vicious state of perinatal infants (\$P\$>0.05). The level of SGOT affected the state of perinatal infants, which there was significant difference between the vicious state group of perinatal infants and the healthy state group of perinatal infants (\$P\$<0.01). Incidence of vicious state of perinatal infants in the group of pruritus lasting time over than 3 weeks was significantly different from that in the group of pruritus lasting time less than 3 weeks (\$P\$<0.05). Incidences of vicious state of perinatal infants had significant differences between the 2 groups with or without NST base line variation or disappearance (\$P\$<0.01).Conclusion The level of SGOT, pruritus lasting time and NST base line variation or disappearance were related indexes which predicted vicious state of perinatal infants.