经股颈外动脉灌注化疗治疗复发性鼻咽癌的临床研究

Clinical study on external carotid artery infusion (trans-femoral) treatrnent of recurrent nasopharyngeal carcinoma

目的 探讨经股颈外动脉灌注化疗对复发性鼻咽癌的治疗价值。方法 2 0例病人 ,男13例、女 7例 ,年龄 36～ 6 5岁、平均 5 0岁 ,均经临床检查 (包括鼻咽镜检 )、血清学检查 (VCA IgA)和影像学检查 (CT、MR)临床确诊为复发性鼻咽癌 ,并行经股颈外动脉灌注化疗 ,主要用药 :阿霉素 (ADM)或表柔比星 (EADM)、顺铂 (DDP)或卡铂 (CBP)、平阳霉素 (PYM)和 5 氟尿嘧啶 (5 Fu)。结果 主要根据世界卫生组织 (WHO)实体瘤测量标准和抗癌药物毒性反应分度标准进行评价 :2 0例中 ,完全缓解(CR) 8例 (40 % ) ,部分缓解 (PR) 7例 (35 % )、无变化 (NC) 5例 (2 5 % )、进展 0例 ,总有效率 (CR +PR)75 %。 1、3年累积生存率分别为 90 % (18/ 2 0 )、5 0 % (10 / 2 0 )。未见严重的毒副反应。结论 经股颈外动脉灌注化疗应为复发性鼻咽癌安全。

Objective To evaluate the effect and safety of external carotid artery infusion treatment of recurrent nasopharyngeal carcinoma (NPC) Methods 20 csaes of recurrent NPC (13 male and 7 female,age 36-65 years,mean 50 years) diagnosed by clinical examination (including nasopharyngolaryngo scope),serology (VCA IgA)and imaging(CT,MR) and treated by external carotid artery infusion (trans femoral) with adriamycin (or epi adriamycin),cisplatin (or carboplatin),pingyangmycin and 5 Fluorouracil Results Of all the patients, 8cases (40%)had a complete response(CR),7 caese(35%)had a partial response (PR) The overall response rate (CR+PR) was 75% Cumulative survival rates at 1,3 years were 90%(18/20),50%(10/20) respectively No severe side effects and complications found Conclusion External carotid artery infusion (trans femoral) should be effective and safe in the treatment of recurrent NPC