肺结核患者初始耐药的流行病学分析

Epidemic analyses of initial drug resistance in patients with pulmonary tuberculosis

目的 了解安徽省结核分支杆菌初始耐药的流行病学特征。方法 将安徽省肺科医院 1997年初～ 1999年底 3年间 2 30例初治肺结核患者的初始耐药性进行流行病学分析。结果 3年的初始耐药率分别为 :1997年 30 4 % ,1998年 2 7 1% ,1999年 2 6 3% ,呈逐年下降趋势 ;异烟肼 (INH)、链霉素 (SM)、利福平 (RFP)的初始耐药率也呈逐年下降趋势。城市初始耐药率 (2 9 7% )高于农村 (2 8 3% )和城镇(2 1 6 % ) ;中老年组初始耐药率高于青年、儿童组 ;不同职业中 ,知识分子具有较高的初始耐药率 33 3% ,学生次之2 9 % ,农民为 2 7 7% ,工人为 2 5 % ;结论 本地区结核病控制工作取得了一定的成效 。

Objective To understand the epidemic characters of initial drug resistance of mycobacerium tuberculosis in Anhui province. Methods 230 new patients of pulmonary tuberculosis in Anhui Lung Hospitals from January 1997 to December 1999 were analyzed with epidemic methods. Results The initial drug resistant rates of three years were 30 4% in 1997, 27 1% in 1998 and 26 3% in 1999 respectively, and down yearly including those of INH, SM, RFP. The initial drug resistant rate of intellectuals was 33 3%; In different careers, the rate of students was 29%, the rate of peasants was 27 7%, the rate of workers was 25%. Conclusion The tuberculosis control program makes some progess in our area, but the initial drug resistance is still a problem.