18例恶性苗勒混合瘤临床病理分析

Clinicopathologic analysis of 18 cases of malignant mixed Müllerian tumor

目的 :探讨女性生殖系统恶性苗勒混合瘤 (MMMT)的临床与病理特征。方法 :对 18例女性生殖系统MMMT进行光镜观察及免疫组化染色 ,结合临床资料进行分析 ,对 9例进行了术后随访。结果 :各部位MMMT的形态特征相似 ,均含有上皮及间叶两种组织成分 ,相互间有穿插和移行变化 ,组织成分形态多样 ,免疫组化有助于判断。恶性度与异型性、核分裂数及出血坏死程度有关。预后与临床分期有关。化疗有效。结论 :MMMT的诊断主要依据组织形态学 。

Purpose To investigate the clinicopathologic feature of malignant mixed Müllerian tumor (MMMT) of the female reproductive system. Methods Microscope observation and immunohistochemical staining, combined with clinical data, were analyzed on 18 cases of MMMT of the female reproductive system, and 9 patients were followed up after operation. Results Morphological changes of MMMT containing epithelial and mesenchymal components with a variety of inter-permeated and transitional changes tissue elements were similar in any parts of the reproductive system. Immunohistochemical staining was beneficial to this disease judgement. Pleomorphism, quantity of nuclear division and severity of hemorrhage and necrosis were associated with malignant changes. Prognosis was relative to clinical stages. Chemotherapy was effective. Conclusion The diagnosis of MMMT is mainly based on tissue morphology and prognosis is relative to clinical stages.