直肠癌中p53基因与血管内皮生长因子表达的关系

The relationship of the expression of p53 and vascular endothelial growth factor in rectal carcinoma

目的 研究直肠癌中血管内皮生长因子 (VEGF)的表达与 p5 3基因之间的关系。 方法 采用免疫组化方法对 4 5例直肠癌标本中VEGF和 p5 3基因的表达进行检测。 结果 在直肠癌中VEGF的表达率为 6 6 .6 7% (30 / 45 ) ,p5 3的表达率为 5 1.11% (2 3/ 45 ) ;在VEGF表达较高的区域 ,p5 3的表达亦较强 ,二者之间具有相关性 (P <0 .0 5 ) ,且与直肠癌的淋巴结转移相关 (P <0 .0 5 )。结论 在直肠癌中 ,VEGF的表达与 p5 3基因的表达呈正相关 。

Objective To investigate the relationship of the expression of p53 and vascular endothelial growth factor (VEGF) in rectal carcinoma .Methods The expression of p53 and VEGF was detected by using immunohistochemical method in 45 Cases of rectal cancer tissue . Results The expression rate of VEGF and p53 was 66.67%(30/45),51.11%(23/45) respectively ; In the areas with higher VEGF expression there was more intensive p53 expression ,χ 2 test showed that VEGF expression was correlated with p53 ( P <0.05).Conclusion VEGF expression was correlated significantly with the expression of p53,and have an important role in metastases of rectal cancer.