放射治疗配合全身化疗治疗局部晚期鼻咽癌

Radiation therapy combined with chemotherapy for locally advanced nasopharyngeal carcinoma

目的 评价放化结合和单独放疗治疗局部晚期鼻咽癌的疗效和毒副反应。方法 将 4 3例鼻咽癌随机分为放化组和单放组。结果 全组 1、3年生存率分别为 88.4 %和 5 1.2 % ,放化组和单放组的 1年生存率分别为 90 .5 %和 86 .4 % (P >0 .0 5 ) ,3年生存率分别为 5 7.1%和 4 5 .5 % (P >0 .0 5 )。放化组的主要毒副反应为恶心、呕吐和白细胞下降 ,发生率分别为 90 .5 %和 10 0 % ,均为Ⅰ～Ⅲ度。结论 研究结果显示POB联合化疗合并放射治疗晚期鼻咽癌是可以耐受的 。

Objective To compare the result and side\|effect of radiation therapy combined with chemotherapy(CRT) and radiation therapy alone(RT) for locally advanced Nasopharyngeal Carcinoma. Mehods 43 patients with for locally advanced nasopharyngeal carcinoma were radomized into two groups:21 entred in the CRT and 22 in the RT group.Results The survival rates of all the patients at 1 and 3\|year were 88.4%,51.2%. The survival rates at 1 and 3\|year were 90.5%, 57.1% in the CRT group and86.4%, 45.5% in the RT group( P >0.05).The main vice\|reaction of CRT group is nausea,vomiting and WBS reducing.The occurrence rates were 90.5% and 100% ,and were Ⅰ～Ⅲgrade.Conclusion Radiation therapy combined with chemotherapy for locally advanced nasopharyngeal carcinomais tolerable. Radiation therapy combined with chemotherapy gives similar results in the survival rates and the local control rates as radiation therapy alon for locally advanced nasopharyngeal carcinoma .No significant differenceis observed.