雷公藤多苷与激素联合应用对哮喘病人血清中IL5的影响

Influence of tripterygiium polyglycoside with hormone on serum IL-5 in patients with asthma

目的 探讨雷公藤多苷与激素联合应用降低哮喘病人血清中IL 5机制。方法 4 0例哮喘病人随机分A、B、C、D四组 ,分别服用雷公藤多苷片TⅡ 、激素、TⅡ 加激素以及对照 ,治疗前后分别测血清中IL 5。结果 治疗后四组血清中IL 5浓度变化差异有显著意义 (P <0 0 0 1)。而A、B、C三组比较差异无显著意义 (P >0 0 5 ) ,治疗后A、B、C三组血清IL 5浓度低于治疗前 (P <0 0 0 1) ,治疗后A、B、C三组血清IL 5浓度低于D组 (P <0 0 0 1)。结论 雷公藤多苷与激素联合应用临床效果与单独应用二药相似 ,但剂量均减少一半 ,从远期效果看剂量小 。

Objective To investigate the influence of tripterygium polyglycoside with hormone on the serum IL 5 in patients with asthma.Methods 40 cases of asthma were divided into four groups(A,B,C,D).Three groups took tripterygium polyglycoside T Ⅱ,hormone,tripterygium polyglycoside T Ⅱ with hormone seperately,the fourth group was used as control.The serum IL 5 was detected pre and post treatment.Results There were significant differences among four groups(P<0.001),but there was no difference among groups A,B,C(P>0.05).Compared with pre treatment,the serum IL 5 of groups A,B,C decreased(P<0.001);Compared with group D,the serum IL 5 also decreased(P<0.001).Conclusion The clinical effect of tripterygium polyglycoside with hormone is similar to using the two drugs alone,but only half of the dosage was used,for long term effect,the side reactions decrease because of lower dosage.