无创机械通气治疗COPD合并Ⅱ型呼吸衰竭疗效研究

Study on curative effect of noninvasive mechanical ventilation in treatment of COPD complicated with type Ⅱ respiratory failure

目的探讨无创机械通气治疗慢性阻塞性肺疾病(COPD)合并II型呼吸衰竭患者中的临床疗效。方法将90例患者随机分为对照组和观察组,各45例,对照组给予常规临床治疗,而观察组在常规治疗的基础上采用无创BiPAP呼吸机联合雾化吸入治疗;比较两组动脉血气指标、心率、呼吸、总有效率、生存质量等指标。结果治疗后,观察组的pH、PaCO2、PaO2、心率、呼吸等指标均明显好于对照组(P<0.01);观察组治疗后的总有效率为82.2%,明显高于对照组的51.1%(P<0.01);观察组治疗后的生存质量得分为96.20±8.93,好于对照组的105.59±7.46(P<0.01)。结论无创机械通气联合雾化吸入治疗COPD合并II型呼吸衰竭患者,可以明显改善心率、呼吸、动脉血气指标,提高总有效率和生存质量。

[Objective]To explore clinical curative effect of noninvasive mechanical ventilation in treatment of chronic obstructive pulmonary diseases（ COPD） complicated with type II respiratory failure. [Methods]90 patients were randomly divided into the control group and the observation group,45 cases in each group. The control group was given the common clinical treatment,and the observation group was treated with noninvasive BiPAP respirator and aerosol inhalation on the basis of common treatment. The arterial blood gas indexes,heart rate,respiration,total effective rate and life of quality were compared between the two groups.[Results]After the treatment,the values of pH,PaCO2,PaO2,heart rate and respiration in the observation group were significantly better than those in the control group（ P 0. 01）. The total effective rate in the observation group was 82. 2%,which was higher than that in the control group（ 51. 1%） significantly（ P 0. 01）. The score of life quality in the observation group was96. 20 ± 8. 93,which was better than that in the control group（ 105. 59 ± 7. 46） significantly（ P 0. 01）.[Conclusion]The noninvasive mechanical ventilation combined with aerosol inhalation can obviously improve the heart rate,respiration and arterial blood gas indexes in patients with COPD complicated with type II respiratory failure,and raise total effective rate and quality of life.