2006-2013年汕头地区病毒性肝炎病原学和血清学监测分析

Pathogenic and serological analysis of viral hepatitis in Shantou,China from 2006 to 2013

目的通过对汕头市病毒性肝炎的病原学和血清学监测分析，了解该地区病毒性肝炎发病情况，为该病的防控提供科学依据。方法4726例肝炎患者血液标本在门诊或住院病人中采集，送至医院检验科实验室，采用ELISA法检测HAV—IgM、HBsAg、HBcAb—IgM、HBcAb、HBeAg、HBeAb、HCV抗体和HEVIgM。结果共检出肝炎病毒抗体阳性4635例，阳性率为98．07％。其中HAV—IgM阳性86例，HBsAg阳性4037例，HBcAb—IgM阳性2220例，HBcAb阳性3514例，HBeAg阳性1122例，HBeAb阳性2253例，HCV抗体阳性165例，HEV—IgM阳性150例，HAV、HBV、HCV、HEV感染率分别为1．82％、89．59％、3．49％和3．17％。乙肝患者中以25～45岁为主，占62．09％。结论汕头地区病毒性肝炎发生率较高，以乙肝感染为主，患者主要为青壮年，需要采取进一步干预措施。

Objective Viral hepatitis was pathogenically and serologically analyzed in the City of Shantou in order to ascertain the prevalence of this disease and provide scientific evidence for its control. Methods Blood samples were collected from 4 726 patients at sentinel hospitals. EIASA was used to detect HAV-IgM, HBsAg, HBcAb-IgM, HBcAb, HBeAg, HBeAb, and antibodies against HCV as markers of viral infection in samples. Results Antibodies against viral hepatitis were detected in 4,635 samples for a rate of detection of 98.1%. HAV-IgM was detected in 86 samples, Hb- sag was detected in 4 037, HBcAb-IgM was detected in 2 200, HbcAb was detected in 4 514, HbeAg was detected in 1 122, HbeAb was detected in 2 220, antibodies against HCV were detected in 165, and HEV-IgM was detected in 150 samples. Conclusion Findings indicated that viral hepatitis B mainly affects young adults in the City of Shantou.