摘要
设计合成了一系列基于脯氨酸巯基咪唑衍生物的新型双亲性有机小分子催化剂,在水相中加入酸作为助催化剂,可以高效高选择性的催化环己酮与硝基烯烃的不对称Michael加成反应,非对映选择性和对映选择性分别高达99:1和96%.
A series of amphiphilic proline-derived mercapto imidazole organic catalysts were synthesized and shown to be very effective with an acid cocatalyst for the asymmetric Michael addition reaction of ketones to nitroolefins with high diastereoselectivity （up to 99：1） and execellent enantioselectivity （up to 96% ） using water as solvent.
出处
《催化学报》
CSCD
北大核心
2014年第7期1008-1011,共4页
基金
supported by the National Natural Science Foundation of China (21002100)
the Fundamental Research Funds for the Central Universities of China (DUT12LK07)~~
关键词
不对称催化
乳液
有机催化
迈克尔加成
Asymmetric catalysis
Emulsion
Organocatalysis
Michael addition
