减重训练及口服二甲双胍对肥胖型多囊卵巢综合征的疗效

Efficacy of weight loss training and oral intake of metformin in obese women with polycystic ovary syndrome

目的 探讨减重训练及口服二甲双胍对肥胖型多囊卵巢综合征的临床治疗效果.方法 将60例肥胖型多囊卵巢综合征作为研究对象,其中单纯减重训练治疗组设为对照组,减重训练和口服二甲双胍组设为观察组,依据治疗方法的不同将患者分为2组,各30例.回顾性分析患者的临床资料,并比较2组临床疗效与安全性.结果 2组治疗后,多毛及痤疮症状均得到有效改善.月经恢复正常对照组53.3％ （16/30）,观察组为96.7％（29/30）,2组有效率比较差异有统计学意义（P=0.000 1）.2组空腹血糖值、体重指数、睾酮水平和黄体生成素水平比较,治疗后均较治疗前有显著改善,观察组的改善效果显著高于对照组,差异具有统计学意义.其中观察组空腹血糖值、体重指数、睾酮水平及黄体生成素水平治疗前后比较差异均具有统计学意义（P值分别为0.003 7,0.001 2,0.002 0及0.002 4）.结论 通过减重训练与口服二甲双胍联合治疗能有效治疗肥胖型多囊卵巢综合征,是目前治疗肥胖型多囊卵巢综合征的主要方法.多囊卵巢综合征的治疗可根据近远期目标的不同选择合适的治疗方法.

Objective To discuss the clinical effect of weight loss training and oral intake of mefformin on obese women with polycystic ovary syndrome.Methods 60 cases of obese women with polycystic ovary syndrome in Nan＇an District Maternal and Child Health Hospital were studied.They were divided into 2 groups,30 cases in each group.The control group received simple weight loss training and the observation group received weight loss training combined with the oral administration of metformin.The clinical data of the 60 cases were retrospectively analyzed and the clinical efficacy and safety of different treatment methods were evaluated.Results After treatment,two groups of patients have been effectively improved.16 cases（53.3％）in the control group and 29 cases（96.7％）in the observation group resumed normal menstruation,and the differences had statistical significance.Fasting blood sugar（FBS）,BMI,testosterone and luteinizing hormone levels of the two groups had significant improvement after treatment,in addition,the improvement of these indicator were more obvious in the observation group than those in the control group,and the difference had statistical significance.The difference of FBS,BMI,testosterone and luteinizing hormone levels had statistical significance between before and after treatment（P =0.003 7,0.001 2,0.002 0 and 0.002 4,respectively）.Conclusion The combination therapy of weight loss training and oral intake of metformin is effective in treating obese women with polycystic ovary syndrome.It is the main method in treating obese women with polycystic ovary syndrome.