普伐他汀对高脂血症患者颈动脉内膜-中层厚度及颈动脉斑块的影响

Effect of Pravastatin on Carotid Intima-media Thickness and Carotid Plaques in Patients with Hyperlipidemia

目的:观察普伐他汀对高脂血症患者颈动脉内膜-中层厚度(IMT)及颈动脉斑块的影响。方法:80例高脂血症伴颈动脉粥样硬化患者按随机数字表法均分为A组和B组。A组患者给予普伐他汀20 mg,口服,qd;B组患者给予普伐他汀40 mg,口服,qd。两组患者疗程均为6个月。观察两组患者治疗前后血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、IMT、颈动脉斑块积分及不良反应发生情况。结果:治疗前两组患者TC、TG、HDL-C、LDL-C、IMT、颈动脉斑块积分比较,差异均无统计学意义(P>0.05)。治疗后两组患者TC、LDL-C、IMT、颈动脉斑块积分均显著低于同组治疗前,且B组显著低于A组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:高剂量普伐他汀可减少IMT,改善颈动脉斑块,减轻颈动脉粥样硬化,且安全性较好。

OBJECTIVE：To observe the effects of pravastatin on carotid intima-media thickness（IMT）and carotid plaques in patients with hyperlipidemia. METHODS：80 patients with carotid artery atherosclerosis complicating with hyperlipemia were randomly divided into group A and group B. Group A was given pravastatin 20 mg,qd,orally;group B was given pravastatin 40 mg,qd,orally. Treatment course of 2 groups lasted for 6 months. The plasma level of TC,TG,LDL-C,HDL-C and IMT,carotid plaque score and ADR were observed in 2 groups before and after treatment. RESULTS：TC,TG,HDL-C,LDL-C,IMT and carotid plaque score had no statistical significance between 2 groups before treatment（P〉0.05）. TC,LDL-C,IMT and carotid plaque score of 2 groups after treatment were significantly lower than before,and those of group B were significantly lower than those of group A;there was statistical significance（P〈0.05）. The incidence of ADR had no statistical significance between 2groups（P〉0.05）. CONCLUSIONS：Pravastatin can reduce IMT,effectively improve the carotid artery plaque and relieve the carotid atherosclerosis.