阿尔茨海默病血浆同型半胱氨酸与超敏C反应蛋白水平的临床研究

Study on the relationship between homocysteine(Hcy)and high sensitivity C reactive protein(hs-CRP)levels in the diagnosis of Alzheimer's disease(AD)

目的探讨同型半胱氨酸水平(Hcy)和超敏C反应蛋白(hs-CRP)与阿尔茨海默病(AD)的病关系。方法选择我院2011年3月—2013年3月住院的AD患者48例,以酶法检测血浆Hcy与hs-CRP水平。另外选择36例2013年3月体检健康者作对照组进行对比分析。结果 AD患者的血浆Hcy与hs-CRP水平与对照组对比均存在差异(P<0.01)。结论 Hcy和hs-CRP共同检测是一种诊断AD的有效指标,高Hcy及高hs-CRP可能是AD发病的又一个重要原因。

Objective To study the relationship between homocysteine（Hcy）and high sensitivity C reactive protein（hs-CRP）levels in the diagnosis of Alzheimer＇s disease（AD）.Methods During the period from 2011 March to 2013 March,48 subjects were selected from inpatients of Baoji City Chinese medicine Hospital and their plasma was tested for the items of Hcy and hs-CRP levels by enzymatic methods. In the meantime,36 health subjects were selected as control group,comparative analysis. Results There were significant differences in Hcy and hs-CRP levels between the test group and control group（both P〈0.01）.Conclusions High Hcy hyperlipidemia and high s-CRP may be an important reason for the pathogenesis of AD.