凉血散瘀、温经通脉方治疗糖尿病周围神经病变临床研究

Clinical Research of Liangxuesanyue and Wenjingtongmai Prescription in Treating Diabetic Perineuropathy

目的:探讨凉血散瘀、温经通脉方辨证治疗糖尿病周围神经病变的临床疗效。方法:45例糖尿病周围神经病变患者随机分为对照组(20例)与治疗组(25例)。对照组给予维生素及能量合剂,治疗组采用自拟中药汤剂口服治疗,8周为1个疗程,1个疗程后统计两组临床疗效、血脂、血液流变学及肌电图检查变化。结果:①治疗组与对照组有效率分别为88.00%、55.00%,两组有效率比较,差异有统计学意义(P<0.05)。②治疗前两组血脂、血液流变学指标比较,差异无统计学意义(P>0.05);治疗后治疗组与对照组比较,血脂、血液流变学均有明显变化,两组比较,差异有统计学意义(P<0.05)。③治疗前两组神经感觉、运动传导速度比较,差异无统计学意义(P>0.05);治疗后与对照组比较均有明显提高,差异有统计学意义(P<0.05)。结论:凉血散瘀、温经通脉方辨治糖尿病周围神经变化临床疗效确切、安全可靠,能有效改善病变部位的血液循环情况,改善血脂黏稠度,并能提高患者的神经传导速度,对糖尿病周围神经病变具有较好的防治作用。

Objective： To investigate the clinical curative effect of of Liangxuesanyue and Wenjingtongmai prescription in treating diabetic perineuropathy. Methods： 45 patients with diabetic perineuropathy were randomly divided into control group（20 cases） and treatment group（25 cases）. The control group was given vitamin and energy mixture and the treatment group was given oral Chinese medicine treatment,eight weeks as a period of treatment. Then statistically analyze the clinical curative effect,blood fat,blood rheology and electromyography of two groups. Results：（1） The effective power was 88. 00% in treatment group and 55. 00% in control group respectively. Compared the efficient of two groups,the difference was statistically significant（P 0. 05）.（2） Compared the blood lipid and blood rheology indexes of two groups before treatment,there was no statistically significant difference（P 0. 05）. But after treatment,the difference was statistically significant（P 0. 05）.（3） Compared the nerve sensory and motor conduction velocity before treatment,there was no statistically significant difference（P 0. 05）. Compared them of two groups after treatment,the difference was statistically significant（P 0. 05）. Conclusion： Liangxuesanyue and Wenjingtongmai prescription in treating diabetic perineuropathy have accurate clinical curative effect,safe and reliable,and can effectively improve the blood circulation of the lesion site,improve the viscosity of blood fat,and can improve the patient＇s nerve conduction velocity,on diabetic peripheral neuropathy having good control effect.