以偏头痛为首发症状的多发性硬化临床分析

Clinical analysis on multiple sclerosis patients with migraine as the primary manifestation

目的探讨多发性硬化(multiple sclerosis,MS)与偏头痛之间的联系。方法回顾性分析以偏头痛样发作为首发症状的7例MS患者临床特点。结果以偏头痛样发作为首发表现的MS患者早期神经功能缺损症状轻微,随后在偏头痛样症状的基础上出现瘫痪、麻木和视觉障碍等典型神经功能缺损症状,影像学表现有明显的幕下病灶,脑干病灶尤为明显。结论偏头痛可能是继发于MS的一种临床表现之一,其机制可能与早期脑干损害有关。

Objective To explore the relationship between multiple sclerosis（MS） and migraine.Methods Clinical characteristics of 7 MS patients with migraine as the first manifestation were retrospectively analyzed.Results There were mild symptoms of neurologic deficiency at the early stage of MS patients with migraine as the primary manifestation.Afterwards,typical neurofunctional defection such as paralysis,numbness and visual disturbances were developed on the basis of migraine.The image analysis showed that there were obvious infratentorial lesions,especially at brainstem.Conclusion Migraine may be one of the clinical manifestations secondary to multiple sclerosis,and the probable mechanism is due to the involvement of brainstem at the early stage.