肿瘤免疫逃逸和免疫抑制的机制和免疫治疗策略的研究进展

Progress in anti-tumor immune mechanisms and treatment strategy

免疫治疗是抗肿瘤治疗的一项重要的辅助治疗手段.有效的激活自身抗肿瘤免疫系统对早期肿瘤的治疗有重要意义.与传统的应用靶点特异性抗体不同,研究者更倾向于对肿瘤组织内部的免疫应答过程进行深入研究,从而期望制定出更有效的肿瘤免疫治疗方案.肿瘤细胞处于不利于诱导抗肿瘤免疫应答的微环境中是肿瘤免疫治疗面临的主要困难之一.

Immunotherapy is an important auxiliary anti-tumor treatment.It has important significance for treatment of early stage tumors by activating antitumor immune system effectively.Instead of novel checkpoint-blocking antibodies,recent insight into innate immune system may further improve cancer immunotherapy strategy and help to overcome the limitations of conventional strategies.A major hurdle for tumor immunotherapy is that the majority of tumor cells are located in an immunosuppressive tumor environment.This paper reviews the novel immunotherapeutic approaches for targeting established cancers.