白细胞介素-14的生物学功能及其与原发性干燥综合征关系的研究进展

The Biological effects of interleukin-14 and its relationship with primary Sj（o）gren＇s syndrome

白细胞介素（IL）-14又称人高分子B细胞生长因子,主要由滤泡树突状细胞和活化的T细胞产生,并特异性地作用于激活后的B淋巴细胞及恶性B淋巴细胞,使之分化增殖.IL-14不仅是调节B细胞功能的重要细胞因子,其受体也是B细胞上的重要功能分子,并且与某些B细胞性肿瘤和自身免疫性疾病密切相关.IL-14-α由IL-14外显子3-10基因编码.研究表明,原发性和继发性干燥综合征患者表达高水平的IL-14-α,IL-14-α的转基因小鼠更是表现出高丙种球蛋白血症、B细胞性非霍奇金淋巴瘤等干燥综合征典型症状,这提示IL-14在干燥综合征的病理生理学中存在重要意义,对其深入研究或为干燥综合征的发病机制及防治提供理论基础.

Interleukin-14（IL-14）,also known as human high molecular B-cell growth factor,is produced by the follicular dendritic cells and activated T cells.IL-4 specifically acts on activated B-lymphocytes and malignant B lymphocytes,promoting their differentiation and proliferation.IL-14 is an important cytokine regulating the function of B cell.The receptor,of IL-4 is also an important functional molecule of B cells is related to B-cell tumors and autoimmune diseases.Interleukin-14-alpha （IL-14-α） is a cytokine encoded by the plus strand of the IL-14 gene using exons 3-10.Studies have shown that patients with primary and secondary Sj（o）gren＇s syndrome express high levels of IL-14-α.Moreover,IL-14-α-transgenic mice demonstrate hypergammaglobulinemia and B-cell Non-Hodgkin＇ s Lymphoma,which are typical complication of Sj（o）gren＇ s syndrome.These studies suggest that IL-14 is rather important in the pathophysiology of Sj（o）gren＇s syndrome.Thoroughly understanding IL-4 might provide basis for the treatment of this disorder.