白细胞介素17A在慢性牙周炎和类风湿性关节炎相关性中的研究

Advance in research on the function of antigen presenting cellsregulated by autophagy

目的 探讨白细胞介素-17A（IL-17A）在慢性牙周炎（CP）和类风湿性关节炎（RA）两者间的相关性.方法 按纳入标准选择85名受试者分为四组：①CP组20例;②RA组23例;③RA伴CP组26例;④HP组16侧;记录牙周袋探诊深度（PD）,临床附着丧失（CAL）和出血指数（BI）,收集其晨起空腹血清并用滤纸条法收集受试者龈沟液样本,采用酶联免疫吸附试验法（ELISA）测定血清及龈沟液中IL-17A的水平.结果 RA＋CP组中血清IL-17A水平（2216.0±1520.87）pg/mL与RA组[（851.59±975.81） pg/mL]、CP组[（1039.7±1004.83） pg/mL]和HP组[（209.48±50.02） pg/mL]差异有统计学意义,RA组和CP组中血清IL-17A水平分别与HP组的差异有统计学意义（P＜0.05）,而龈沟液中的IL-17A水平在HP组[（356.75±69.07） pg/mL],RA组[（381.08±79.48） pg/mL],CP组[（397.82±108.53） pg/mL]以及RA＋CP组[（414.71±103.09） pg/mL]间呈现升高趋势,但无统计学差异（P＞0.05）.结论 IL-17A可能在慢性牙周炎和类风湿性关节炎相关性的研究中具有一定的意义.

Objective This present study was to detect the role of IL-17A on the correlation between chronic periodontitis（CP） and rheumatoid arthritis（RA）.Methods According to the inclusion criteria selected 85 subjects were detected into four groups：①20 patients with chronic periodontitis;②23 patients with the RA;②26 patients with CP and RA;④16 healthy numbers as the control group.The clinical periodontal parameters including probing depth （PD）,clinical attachment loss（CA L）,and bleeding index（BI） were examined,and the serum and GCF levels of IL-17A were measured by enzyme-linked immunosorbent assay（ELISA）.Results The IL-17A levels in serum of patients with CP and RA[（2216.0 ± 1520.87）pg/mL]were significantly higher than the RA group [（851.59 ± 975.81） pg/mL],CP group [（1039.7 ± 1004.83） pg/mL] and the control group[（209.48 ± 50.02）pg/mL].Serum levels of IL-17A in CP group and RA group were significantly higher than the healthy control group（P ＜0.05）.The IL-17A levels in GCF of in the HP group[（356.75 ±69.07）pg/mL],RA group[（381.08 ± 79.48） pg/mL]/CP group [（397.82 ± 108.53） pg/mL] and patients with CP and RA[（414.71 ± 103.09）pg/mL] showed a trend of increase,but no statistical difference （P ＞0.05）.Conclusions IL-17A may have some significance in the study of the correlation between chronic periodontitis and rheumatoid arthritis.