中医药添加治疗儿童难治性癫痫的研究现状

The research status on adding the treatment of intractable epilepsy in children by traditional Chinese medicine

目前难治性癫痫治疗效果不甚理想,故寻找疗效明确,副作用小的治疗手段十分迫切。近年来不少学者提出难治性癫痫病因病机及治疗手段的新观点,笔者根据自己多年临床经验采用中医药添加治疗手段治疗儿童难治性癫痫,取得了一定疗效,肯定了中医药在增强抗癫痫药物的抗痫作用的同时,也证实了中医药具备整体调节,提高患儿的生活质量,且不良反应少的优势。实验研究方面,进一步探究中医药治疗手段在抗癫痫作用的机理,主要针对其对多药耐药基因相关蛋白表达增多、神经网络重组的影响上。

Since currently the efficacy of treating intractable epilepsy with western medicine is not very ideal,to find a new treatment with clear efficacy and small side effects is very urgent. In recent years, many traditional Chinese medicine （TCM）scholars proposed new etiology,pathogenesis and treating prin-ciple for intractable epilepsy and treated it with added TCM methods based on their years of clinical experi-ence. The treatments have gotten certain achievement,which not only affirmed that TCM could enhance the action of antiepileptic drugs （AEDs）,but also confirmed the advantages of TCM,such as holistic regula-tion,improving the patient＇s quality of life with less adverse reaction. There were also certain experimental researches that further explored the antiepileptic mechanism of TCM from the following points：increased expression of the multi-drug resistance （MDR）gene related protein,and influence to neural network re-structuring. Here we summarize the relative research status as following.