醒睡安方加减治疗发作性睡病46例临床观察

Clinical Observation on Modified Xingshuian Formula for 46 Cases of Narcolepsy

目的观察醒睡安方加减治疗发作性睡病的临床疗效。方法对46例发作性睡病患者采用醒睡安方加减治疗,每日1剂。治疗6个月后评价近期疗效,并于停药6个月后进行随访评价远期疗效。观察治疗后症状(白天嗜睡、体重增加、猝倒、恐惧感、食欲亢进、睡瘫、多梦、幻觉、情绪暴躁、腿软、睡中抽动、睡语、吐舌)的有效率。结果近期疗效总有效率为95.7%。远期疗效总有效率为80.4%。治疗后各症状病例数均有减少,其中白天嗜睡、体重增加、猝倒、恐惧感、食欲亢进、睡瘫、多梦、幻觉症状有效率>60.0%。结论醒睡安方加减治疗发作性睡病能明显改善临床症状,有较好疗效。

Objective To observe the efficacy of modified Xingshuian Formula （ formula for carmful sleepy, 醒睡安方） for narcolepsy. Methods Totally 46 cases of narcolepsy were given modified Xingshuian Formula one dose daily. The short-term efficacy was evaluated after 6-month treatment. The patients were followed up and the long-term efficacy was evaluated 6 months after withdrawal. The effective rates of symptoms such as daytime sleepiness, weight gain, cataplexy, sense of fear, appetite hyperactivity, sleep paralysis, dreaminess, hallucinations, irritability, sleep twitching and sleep talking were observed. Results The total short-term efficacy and long-term efficacy was 95.7% and 80.4% respectively. All the symptoms were reduced after treatment. The eifective rates of daytime sleepiness, weight gain, cataplexy, sense of fear, appetite hyperactivity, sleep paralysis, dreaminess and hallucinations were higher than 60. 0%. Conclusion Modified Xingshuian Formula is effective for narcolepsy and it can obviously relieve the symptoms.