衰老机体中血管内皮细胞的损伤调控机制

Endothelial Cell Damaging mechanism in Aging Organism

衰老表现在机体多方面的变化,从各种组织器官的功能障碍,到细胞内结构变化。近年来,关于衰老与内皮细胞损伤的研究越来越受到关注。衰老机体中内皮细胞通过多种途径导致自身结构功能发生一系列改变,最终使其损伤。本文综述了衰老机体中,内皮细胞功能发生的变化,着重讨论衰老机体中诱导内皮细胞损伤的多种通路的作用机制,同时论述了作用于各通路的相关调节因子,为延缓衰老机体内皮损伤提供可能的策略。

Aging includes various changes,from the dysfunction of different organs to cellular damages.Recent years,there is a growing attention on the relationship between aging and endothelial cell damage.Aging bodies＇ endothelial cells are damaged through many ways,all contribute to structural and functional changes.And these pathways are being researched more and more deeply.This paper reviews the change of aging organism and the effects on endothelial cells,focuses on the different pathways on endothelial damage,and also discusses the relevant regulatory factors,which can be treated as new direction for inhibiting endothelial damages and provide relevant strategies for delaying damages.