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PIP2对外周伤害性信息整合器TRPV1活性的调控作用 被引量:1

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摘要 瞬时受体电位香草酸亚型1(transient receptor potential vanilloid subfamily,member 1,TRPV1)是瞬时电压感受器阳离子通道(transient receptor potential cation channel,TRP)家族成员之一,可被伤害性热刺激或一些化学分子所激活,在热痛觉敏化形成过程中发挥重要作用,其功能活性在转录后水平受到多种方式的调控。近年来,磷脂酰肌醇4,5二磷酸(phosphatidylinositol 4,5-bisphosphate,PIP2)调节离子通道活性的研究不断深入,因此PIP2对TRPV1的调控作用受到愈来愈多的关注,但研究结果尚存一些争议。本文着重就近年来,对于PIP2对TRPV1的活性调控以及二者之间的结合等方面的研究进展加以整理和总结。
出处 《生理科学进展》 CAS CSCD 北大核心 2014年第3期209-212,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30830044 30925015 81161120497 91332119 31371143)资助课题
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