中国人群单核苷酸多态性与原发性肺癌易感性的相关性研究

Association between single nucleotide polymorphisms and non-small cell lung cancer in Chinese population: a casecontrol study

目的探讨STAT6的rs1059513位点以及IL-13 rs20541,IL-4R rs1801275位点的SNP多态性,分析比较与非小细胞肺癌的遗传易感性的关系。方法采用Taqman基因分型技术,分析比较468例健康对照者与262例原发性肺癌患者的基因型与非小细胞肺癌的遗传易感性的关系。结果 STAT6基因型rs1059513(C/T)位点基因型(TT)在病例组和对照组中的频率分别为83.6%和85.9%,基因型(C/T)频率分别为16.4%和13.9%,基因型(C/T+CC)在病例组和对照组的频率分别为16.4%和14.1%;IL13基因rs20541(C/T)位点基因型(CC)在病例组和对照组的频率分别为7.63%和8.12%,基因型(C/T+TT)在病例组和对照组中的频率分别为92.4%和91.6%;IL4R基因rs1801275(A/G)位点基因型(AA)在病例组和对照组的频率分别为65.6%和68.8%,基因型(A/G+GG)在病例组和对照组中的频率分别为34.4%和31.2%。各位点多态性在病例组和对照组中的分布频率均P>0.05。结论上述位点多态性与肺癌均没有显著性相关。

Objective To evaluate the role of STAT6 rs1059513,IL-13 rs20541 and IL-4R rs1801275 single nucleotide polymorphisms（ SNPs） as risk factors in non-small cell lung cancer patients. Methods A total of 468 healthy controls and262 cases of primary lung cancer patients were recruited for this study. Genotypes were determined by using Taqman technology. Results The genotypes frequencies of STAT6 rs1059513 in case group were TT 83. 6%,CT 16. 4%,CT ＋ CC 16. 4%,and in control group were TT85. 9%,CT 13. 9%,CT ＋ CC 14. 1%,respectively. The genotypes frequencies of IL13 rs20541in case group were CC 7. 63%,CT ＋ TT 92. 4%,and in control group were CC 8. 12%,CT ＋ TT 91. 6%,respectively. The genotypes frequencies of IL4R rs1801275 in case group were AA 65. 6%,A /G ＋ GG 34. 4%,and in control group were AA68. 8%,A /G ＋ GG 31. 2%,respectively. The distribution of polymorphism frequencies in the case group and the control group were P 0. 05. Conclusion There was no statistically significant association between the case group and the control group for all the genotypes above.