阿托伐他汀20mg辅治对2型糖尿病合并颈动脉粥样硬化患者疗效及安全性的系统评价

Treating type 2 diabetes mellitus with carotid artery atherosclerosis by atorvastatin(20 mg) therapy:a Meta-analysis of efficacy and safety

目的系统评价阿托伐他汀20 mg辅治2型糖尿病合并颈动脉粥样硬化患者的有效性和安全性。方法计算机检索中国生物医学文献数据库、中国期刊全文数据库、万方期刊数据库等及手工检索相关文献,查找有关阿托伐他汀20 mg治疗2型糖尿病合并颈动脉粥样硬化患者的随机对照试验,按照Cochrane系统评价的方法,客观评价纳入文献的质量,提取有效数据,采用RevMan 5.2软件进行Meta分析。结果共纳入6个随机对照试验,包括.545例患者。结果显示,与糖尿病常规治疗或糖尿病常规治疗联合阿托伐他汀10 mg比较,糖尿病常规治疗联合阿托伐他汀20 mg能降低颈动脉内中膜厚度（IMT）（SMD=0.96,95%CI 0.50～1.43,P〈0.01）,不良事件发生率差异无统计学意义（OR=0.47,95%CI 0.18～1.22,p＞0.05）。结论阿托伐他汀20 mg辅治2型糖尿病合并颈动脉粥样硬化患者是有效和安全的。

Objective To systematic review the effectiveness and safety of 20 mg atorvastatin treatment in type 2 diabetes with carotid atherosclerosis.Methods Computer retrieval China biomedical literature database,China periodical full text database,Wanfang periodical database and manual search of relevant literature to find the randomized controlled trial of using 20 mg atorvastatin in treatment of type 2 diabetic patients with carotid artery atherosclerosis,according to the Cochrane system evaluation method,the objective evaluation of the quality of literature in the extraction of effective data,Meta-analysis were analyzed by RevMan S.2 software.Results 6 randomized controlled trials,including 54 S patients were enrolled.The results showed that,with the conventional treatment of diabetes or combined with atorvastatin 10 mg,the conventional treatment of diabetes combined with atorvastatin 20 mg can reduce the carotid artery intima-media thickness（IMT）（SMD =0.%,95%CI 0.50-1.43,P〈0.01）,adverse event rates were not statistically significant（OR = 0.47,95%CI 0.18- 1.22,P 〉0.05）.Conclusion It demonstrated that atorvastatin（20 mg） in treatment of type 2 diabetes with carotid atherosclerosis is effective and safety.