静脉滴注盐酸氨溴素治疗小儿肺炎的安全性及可行性分析

Safety and Feasibility of Intravenous Injection of Ambroxol Hydrochloride in Treating Children with Pneumonia

目的分析静脉滴注盐酸氨溴素治疗小儿肺炎的安全性及可行性。方法选取我院2011年12月—2012年4月收治的小儿肺炎患儿60例,随机分为对照组30例和观察组30例。对照组患儿给予常规治疗,观察组患儿在常规治疗基础上给予盐酸氨溴素15 mg静脉滴注。比较两组患儿临床疗效。结果对照组总有效率为80.0%(24/30),观察组为93.3%(28/30),观察组总有效率高于对照组(P<0.05)。观察组患儿肺部啰音消失时间、临床症状消失时间及退热时间短于对照组,每天吸痰次数少于对照组(P<0.05)。两组患儿在治疗过程中均未出现严重不良反应,观察组3例患儿、对照组5例患儿出现轻微呕吐、恶心、发热。结论静脉滴注盐酸氨溴素治疗小儿肺炎疗效确切,安全可行,值得在临床推广和应用。

Objective To investigate the safety and feasibility of intravenous injection of ambroxol hydrochloride in treating children with pneumonia. Methods From December 2011 to April 2012,60 children with pneumonia in our hospital were chosen and randomly divided into groups control and observation,each of 30 cases. The control group was treated with rou-tine treatment,while the observation group given intravenous injection of ambroxol hydrochloride based on the routine treatment, 15 mg/ time. The clinical efficacy was compared between the two groups. Results The total effective rate of observation group was 93. 33% ,was significantly higher than that of control group of 80. 0%（ P 〈 0. 05）. The time of pulmonary rales disap-peared,clinical symptoms disappeared,fever disappeared in observation group were shorter than those in control group,and times of sputum suction less（P 〈 0. 05）. No one in the two groups occurred severe adverse reactions,but 3 cases in observation group,5 cases in control group occurred slight vomit,nausea and fever. Conclusion Intravenous injection of ambroxol hydrochlo-ride in treating children with pneumonia is effective,safe and feasible,and is worthy of application and promotion on clinical.