培土解毒方联合化疗治疗非小细胞肺癌30例临床观察

Treatment of Non-small-cell Lung Cancer with Chemotherapy and Peitu Jiedu Decoction

目的观察培土解毒方联合化疗治疗非小细胞肺癌患者的临床疗效。方法将60例非小细胞肺癌患者随机分为2组:对照组(30例)给予PC方案化疗4周期,21d为1周期,治疗组(30例)在对照组治疗基础上加培土解毒方口服。观察患者治疗前后主要症状、体征、肿瘤标志物、血清VEGF变化情况。结果 2组治疗后中医证候总积分有明显差异(P<0.05),治疗组血白细胞减少、恶心呕吐及纳差乏力发生率与对照组比较有统计学意义。治疗后治疗组患者血清VEGF浓度较治疗前明显降低,与对照组比较差异有统计学意义(P<0.05)。结论培土解毒方联合化疗对非小细胞肺癌患者的疗效满意。

Objective To observe the clinical efficacy of Chinese medicine Peitu Jiedu decoction combined with chemotherapy in treating non-small-cell lung cancer. Methods 60 patients of non-small-cell lung cancer were randomized into two groups. 30 cases in the control group were treated with only chemotherapy（PC regimen）for 4 periods,and the other 30 cases in the study group were treated with chemotherapy and Peitu Jiedu decoction. The changes of symptoms,signs,serum tumor markers and serum VEGF were observed before and after treatment. Results The total Chinese medicine symptom credits of two gourps were significantly different after treatment. Compared with control group,the occurrence of WBC reduction,nausea,vomit,anorexia and maransis in the study group is remarkably lower after treatment. And the serum VEGF concentration is obviously lower after treatment in the study group,which had a significant difference comparing with control group. Conclusion Peitu Jiedu decoction in treating non-small-cell lung cancer can get satisfied therapeutic effect.