代谢综合征与非酒精性脂肪肝临床特征的关系

The Relationship Between Metabolic Syndrome and Clinical Features of Non-alcoholic Fatty Liver Diseas

目的:探讨代谢综合征(metabolic syndrome,MS)与非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)临床特征之间的相关性。方法:从我院2012年1月-2014年2月健康体检资料中抽选326例经超声确诊为NAFLD的患者,作为NAFLD组,并随机抽选335例无脂肪肝患者作为对照组;观察两组患者间的临床特征,并采用Logistic回归分析MS与NAFLD临床特征之间的相关性。结果:NAFLD组患者体重指数(BMI)、血压、丙氨酸氨基转移酶(ALT)、空腹血糖(FBG)、血尿酸(UA)、高密度脂蛋白(HDL-C)、甘油三酯(TG)、天冬氨酸氨基转移酶(AST)水平显著高于对照组(P<0.05):两组间低密度脂蛋白(LDL-C)、总胆固醇(TC)比较无显著性(P>0.05)。NAFLD组中MS、血脂及糖代谢异常、肥胖以及高血压的检出率明显高于对照组(P<0.05)。经Logistic回归分析显示,NAFLD、BMI、TG、HDL-C、高血压及血糖是MS的独立危险因素。结论:NAFLD患者中存在MS的各种组分聚集特征,MS患病率明显升高,NAFLD是MS的独立危险因素之一,因此MS与NAFLD关系密切。

Objective： To investigate the relationship between metabolic syndrome and clinical features of non-alcoholic fatty liv- er disease. Methods： 326 patients with NAFLD diagnosed via ultrasound in physical examination data from January 2012 to February 2012 were selected as the NAFLD group, and 335 patients without fatty liver were randomly selected as the control group.Clinical fea- tures between two groups of patients were observed, and the correlation between MS and NAFLD clinical features was analyzed by the Logistic regression analysis. Results： In NAFLD group, body mass index （BMI）, blood pressure, alanine aminotransferase （ALT）, fasting blood glucose （FBG）, blood uric acid （UA）, high-density lipoprotein （HDL- C）, triglyceride （TG）, aspartate aminotransferase （AST） were significantly higher than those of the control group （P〈0.05）, there was no significant differences in low density lipoprotein cholesterol （LDL - C）, total cholesterol （TC） between the two groups （P〉0.05）. In NAFLD group, the detection rates of MS, abnormal blood lipid, abnormal glucose metabolism, obesity arid hypertension were much higher than those of the control group （P〈0.05）. The Logistic regres- sion analysis showed that NAFLD, BMI, TG, HDL - C, high blood pressure and blood sugar were independent risk factors of MS. Con- clusion： There are various and gathered characteristics components in patients with NAFLD, and the prevalence of MS increased signifi- cantly. NAFLD is one of the independent risk factors of MS, so MS is closely associated with NAFLD.