黄芪对实验性肝纤维化组织ICAM-1表达影响的免疫组化研究

ICAM-1 expression in experimental fibrosistissue affected by Radis Astragali

目的观察黄芪抗肝纤维化的疗效并探讨其机理。方法用黄芪治疗CCl4 诱导的肝纤维化模型 ,观察它对血清HA、肝组织纤维化评分及ICAM_1表达的影响。结果黄芪组肝纤维化评分及血清HA明显低于模型组 ,肝组织中ICAM_1阳性细胞数明显减少。结论黄芪有良好的抗肝纤维化作用 。

Aim To observe the antifibrotic effect of Radis Astragali and to explore the mechanism. Methods The fibrosis of animal model was induced with CCl4,and the model animals were treated with Radis Astragali in treatment group and saline in control group respectively. Results The serum hyaluronic acid (HA), fibrosis score and ICAM_1_positive hepatocytes all the decreased in the treatment group as compared to those in the control group.Conclusion Radis Astragali has satisfactory effect on experimental fibrosis. The mechanism may be correlated with its affection on ICAM_1 in liver tissue.