247例手术切除的老年肺癌患者临床病理特点分析

Analysis on clinical pathological characteristics of 247 senile lung cancer patients

目的探讨手术切除老年肺癌患者临床病理特点,为临床的诊治工作提供理论依据。方法对经手术切除的247例≥60岁的肺癌患者临床病理资料及肿瘤位置进行统计学分析。结果 247例患者男:女=2.38:1(174/73),鳞癌、腺癌及小细胞癌所占的比例分别为36.8%、52.6%和4.9%。男女间病理类型构成有显著性差异(P=0.002),女性患腺癌的比率是男性的1.59倍。男女患者的吸烟率分别为69.5%和32.9%(χ2=28.512,P=0.000)。鳞癌、腺癌、小细胞癌患者吸烟率分别为67.0%、50.8%、75.0%。吸烟者患鳞癌的比例高于腺癌(P=0.016);周边型肺癌∶中心型肺癌=3.1∶1,中心型肺癌吸烟的比例大,周边型肺癌中吸烟与不吸烟所占的比例相差不大;发生在右肺叶的为150例,左肺叶是97例。首发症状以咳嗽和咯痰带血为最常见。结论手术切除的老年肺癌患者以男性、周边型及腺癌为多,女性患腺癌的比例高。吸烟者易患肺鳞癌,以中心型肺癌为多。

【Objective】To investigate the clinical pathological characteristics of senile lung cancers patients after surgery in order to provide scientific basis for clinical diagnosis and treatment. 【Methods】The statistical analysis was used to analyze the clinical pathological data and tumor locations of 247 senile lung cancer patients（age ≥60years） after surgery.【Results】Among the 247 patients, the ratio of male to female was 2.38：1（174/73）, Lung squamous cell carcinoma accounted for 36.8%, Adenocarcinoma 52.6% and SCLC 4.9%. There was a statistically significant difference（P =0.002） in pathological types between males and females. The femalepatientswith Adenocarcinoma were 1.59 times of male. The smoking rate of male and female were 69.5% and 32.9% respectively（χ^2= 28.512, P =0.000）. Smokers accounted for 67.0 %, 50.8% and 75.0% respectively in squamous cell carcinoma, lung adenocarcinoma and small cell lung cancer and smoker has a higher rate in squamous cell carcinoma than that in adenocarcinoma（P =0.016）. The ratio of peripheral lung cancer to central lung cancer was 3.1：1. Smoking rate is higher in central lung cancer. And in peripheral lung cancer, there was no significant difference between smoker and non-smoker.There were 150 cases with cancer in the right lung and 97 cases in the left. The most common first symptoms were cough and sputum with blood. 【Conclusions】In senile patients with lung cancer after surgery appears more frequently in males, peripheral carcinoma and adenocarcinoma. Female has a high rate in adenocarcinoma than male.Smoking patients are more likely to get central and squamous cell carcinoma.