呋塞米的鼻腔吸收及薄荷醇的促进作用

Nasal absorption of furosemide and promotion action of l-menthol

目的探讨呋塞米的鼻腔吸收及薄荷醇的促进作用。方法采用大鼠在体鼻重循环方法 ,研究呋塞米鼻腔吸收的量效关系及薄荷醇对其鼻腔吸收的影响。结果循环液中呋塞米的浓度在(4.66±0.33 )、(9.76±0.45)、(18.83±1.89) μg·ml-1 时 ,鼻腔的吸收速率常数 (min-1)分别为0.0067±0.0011、0.0134±0.0024、0.0163±0.0037 ,尿液出现时间则分别为 (73.33±1.53)、(52.67±7.02)和 (47.00±4.58)min ;但随着薄荷醇浓度的增加 ,呋塞米的吸收速率常数反而减少。

Aim The nasal absorption of furosemide and promotion action of l_menthol was examined. Methods In situ nasal recirculation methods was used to study the does_effect relationship of nasal absorption of furosemide and the effect of l_menthol on nasal absorption of furosemide in rats. Results When the concentration of furosemide in circulation liquid was respectively(4.66±0.33) ?(9.76±0.45) and (18.83±1.89) μg·ml-1,the absorption rate constant k(min-1) of nasal in situ was correspondingly 0.0067±0.0011,0.0134±0.0024 and 0.0163±0.0037;and urine liquid appearing time was (73.33±1.53)?(52.67±7.02) and (47.00±4.58) min.But the larger the concentration of l_menthol, the little the absorption rate constant k. Conclusion Furosemide can be absorbed through the nasal mucous, and l_menthol can promote its absorption.